My favorite - 1911 Springfield V16 Longslide in 45super........
I love my Colt goverment model 45ACP but for hunting I carry my Ruger Black Hawk 41 mag.
I would have to say, my BFR in 500 Mag, followed by my BFR in 45-70 then my 4 inch S&W 500 Mag and I have a few more that I like a lot. 
Well i've got very limitted experience with handguns but glock 17, colt or kimber 1911, and a ruger .357were the ones i shot best and that felt most comfortable to me.
My fav is the Glock 22. The first time I held it, it was like it was made for my hand. My friends say I am crazy cause the gun is odd for them. I love to shoot this gun! I know how it shoots, how to hold it the best for me etc.
As far as auto's go, no question 1911's are my fav. I have a Smith 586 357 that I love too.
My Taurus Millenium .380 is the best shooting pistol I've ever shot, BUT I also have a Hi-Point 45 that shoots good, too. I know that Hi-points are often "bashed", because of their low cost, but they are made right here in the US, and they have a lifetime warranty. My .45 has never jammed yet, and I would have alot of faith in the gun if I needed to use it. Try one sometimes.....you may like it. 
Love shoting my SUPER RED HAWK .44 magnum stainless ... but looking for a good .45
Of my own guns I love to shoot my Taurus .357 total titanium. Powerful, accurate and super light. My s&w .40 shoots very well for a $300 gun. I can hit beer cans from 15 yards with it and I'm not a very good shot.
My favorite is the EAA Witness 9mm, in the wonder finish. It's comfortable, and well balanced. Plus, it turned out to be more accurate than my target pistols, with adjustable sights.
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