I think a lot of comments got mixed up on this thread... and the Original question of which would be the best bullet choice for His 30-06.
No one including myself advocated or endorsed shooting a 130# max wt. animal out to 400; However the differences in Drop (even with elevation) between a 150 gr bullet and a 180 are great... it isn't whether the bullet size is substancial or not for Antelope... because both will kill the animal Dead...
In sighting in the bullet say 1.5 inches high at 100 and then shooting at various ranges from 100 to 200 and then out to 300 the 150, 165, and 180 have a large difference in regards to pull of gravity. The effective range of each depends on how much elevation is given when sighting in. The (drop) of the bullet in practical hunting terms need to be looked at and tried on the range before Picking a bullet to do what you want it to.
I believe that a person needs to actually go out to the range with one gun... all three boxes of shells spoken about here and shoot at the same target, same yardage etc... with all three bullet weights looking at the different points of impact when shooting at 100,200 and 300 yards befor giving another reply to this question.