When you sight in for MPBR you hold dead on all the way out to MPBR! Not to 400yds. Anything beyond the max range you have your rifle sighted in for it going to require hold over of some type. If you sight in for zero at 200yds, you then need to find out at what point you have to start holding over. Now if you do in fact sight in for zero at 200yds, you WILL have a MPBR of something. And it will probably be closer than what it could be. That means you start raising the sights sooner.
Here is the real truth. Used a BC for the 180gr partition gold and data from the 30-06 Ackley. I don't data it for the 180 accubond, won't be that much difference. Used a velocity of 2900fps for both methods, doable in the Nosler manual. Figures arrived at with Pact MK IV cronograph's computer. 8" target used for MPBR. I would be happy to re-do this with the 30-06 Springfield if you like. This only shows a comparision of sighting techniques.
200 yd zero 100 yds - +1.6" 200 yds - +.0" 300yds - -7.4" 400yds - -21" 500yds - -41.9"
MPBR 8" target 100yds-+3.3" 200yds-+3.4" 300yds -2.2" 400yds--14.1" 500yds--33.3"
Now I have done these balistic tables for my own rifles a lot using the same method and my number's for ranges and retained velocities match published balistics. In the above case I didn't have the right BC but, the same BC was used for both methods. So much for crap, crap, crap! Using the MPBR over zero at 200 gives you 7.6" less drop at 500yds! My computer will also give you remaining velocity at all those yds and I have the formular for remaining energy if you'd like it. If you';d like to use a different BC and velocity tell me what it is and I will be glad to dun it for you.
Have a nice day!