25-06 shooting a 120g Nozler Partition has killed more mule deer and antelope for me than any other gun. It's comfortable to shoot, will reach out and do the job. Most of my shots have been on the 200-400 yard range.
I broke the stock on my 25-06 and bought a new 270WSM, But I will buy another 25-06.
My .264 Win Mag that I just finished building on time for deer season. I have two Colorado tags, a New Mexico tag, a California tag (which I may eat, not sure I can pull that one off too) and two Maine tags for her to fill with me this year. 140 gr Nosler Partitions, 65 gr. IMR 7828SSC, Federal Gold Medal Match Primers. Velocity 3150 fps out of the 27 inch Lilja barrel. Mild recoil, long bullets for good penetration and high ballistic coeffecients. Sweet shooting gun! Been borrowing my buddy's custom .264 off and on for years before I built mine.
Others have offered up a sighting of roughly 2 inches high at 100 yards as a good sighting scheme. In my own experience I have come to favor a sighting of 3.5 inches high at 100 yards. This allows for the individual to hold dead-on (directly in the middle of the top and bottom) the animal out to roughly 350 yards.
Magnum calibers such as the 7mm Remington and 300 Winchester will extend this slightly. At 400 yards I hold directly on the backbone of the animal. The drop at this range allows the...