I've never had to opportunity to hunt elk, but a 280 will certainly shorten the like span of a bull mose in a hurry. Shot placement always critical regardless of calibre. http://www.chuckhawks.com/280Rem.htm
280 Remington shooting 160-gr. Nosler AccuBonds or Partitions is great elk medicine. If this fine cartridge had been introduced 3 years earlier, then Winchester might not have even brought the 270 to market and we'd be ranting about the improved 280 Rem rather than the 270.
In the spring of 2007 I was the unfortunate recipient of an injury cause by a damaged carbon arrow that shattered on release of the arrow. I was in the yard going to take a few practice shots before dinner and the second arrow is the one that did the damage. That day will forever be burned in my mind. After I release what happened I made mistake #2 I pulled the tail shaft of the arrow out of my hand causing more damage.
Thank goodness that my wife was home and was able to...