well the greatest hunter i know ( myself) thinks the 338 is just about perfect. I like the 375 H&H, I like the 416 Rem mag, I like, no love my 280 rem, the 243 is an excellent cartridge, heck a 223 and a dog town and i'm in heaven. Even a 22 lr and a bunch of friend trying to out shoot each other is great. But, when I'm going after a trophy of a lifetime my Remington 700 in 338 win mag with a 2.5 x 8 Leupold scope is going with me. Irregardless if its a coastal brown bear or a full curl Dall sheep.