I had a friend who was practicing with his new .416 for his upcoming Cape Buffalo hunt. He was using it to shoot out of his second story window at ground squirrels in his pasture. Any squirrels that he missed got new holes to hide in.
To specifically answer your question, it is my understanding that the .22-250 was originally developed as a varmint cartridge, and with the right bullets it has been successfully used on deer sized (and larger) animals. I've shot both mule deer and antelope with mine. I have friends who have shot elk and buffalo with theirs.
And the .25-05 was originally developed as a deer cartridge that would also work well on long range shots on varmints on windy days. I've used my .257 AI, which is balistically similar to the .25-06, on everything from prairie dogs to elk. It's my favorite deer, antelope, and bighorn sheep rifle.
There can be too much of a good thing with antler rattling.
I like to hit the horns together for a good 30- to 40-second rattling sequence and then hang them up and resist the urge to hit them again.
This works to the hunter's advantage, because if a buck has heard it, he may have been 300 or 400 yards away and he comes in and he's not exactly sure where it came from.
When finally is time to rattle again throw a slight change-up into the routine.
The second time, don't rattle as loud...