I had a friend who was practicing with his new .416 for his upcoming Cape Buffalo hunt. He was using it to shoot out of his second story window at ground squirrels in his pasture. Any squirrels that he missed got new holes to hide in.
To specifically answer your question, it is my understanding that the .22-250 was originally developed as a varmint cartridge, and with the right bullets it has been successfully used on deer sized (and larger) animals. I've shot both mule deer and antelope with mine. I have friends who have shot elk and buffalo with theirs.
And the .25-05 was originally developed as a deer cartridge that would also work well on long range shots on varmints on windy days. I've used my .257 AI, which is balistically similar to the .25-06, on everything from prairie dogs to elk. It's my favorite deer, antelope, and bighorn sheep rifle.
Have you ever looked all over the house and garage for a piece of hunting equipment or an article of clothing? I sure have... or at least I used to. I found that storing my hunting gear in large containers that are labeled not only saves me time looking but also saves space. I used to have my gear all over the house, taking up space that I needed for other things.
Here's what I do now. I went out and bought some large plastic tubs and everything goes in them. I...