I had a friend who was practicing with his new .416 for his upcoming Cape Buffalo hunt. He was using it to shoot out of his second story window at ground squirrels in his pasture. Any squirrels that he missed got new holes to hide in.
To specifically answer your question, it is my understanding that the .22-250 was originally developed as a varmint cartridge, and with the right bullets it has been successfully used on deer sized (and larger) animals. I've shot both mule deer and antelope with mine. I have friends who have shot elk and buffalo with theirs.
And the .25-05 was originally developed as a deer cartridge that would also work well on long range shots on varmints on windy days. I've used my .257 AI, which is balistically similar to the .25-06, on everything from prairie dogs to elk. It's my favorite deer, antelope, and bighorn sheep rifle.
All of us, at one time or another have gone on a hunting trip and had what we call “Blue Bird” weather. Warm evenings and almost hot days. We hunt in our t-shirts and enjoy the sunshine. We are way up in the mountains and have a whole week to hunt. How could it get any better?
That is, until we score on that big buck or bull. We work to get it out of the field and skinned as quickly as possible to cool it down. But try as we might, we just can’t get...