It would depend on the game. I think it is more than adequate for any dangerous game in N. America. If you are heading out of NA you may want something with a little more punch. Do you reload for it? It is not very common anymore. I had the pleasure of shooting one a few years back and it was like going back in time. It is a great round though.
Probably not - we've all heard the stories about charging bears that were "dead bears running" but kept coming anyway. It's definitely more than enough round to kill any dangerous game - but once they charge all bets are off short of a head or spine shot.
In the spring of 2007 I was the unfortunate recipient of an injury cause by a damaged carbon arrow that shattered on release of the arrow. I was in the yard going to take a few practice shots before dinner and the second arrow is the one that did the damage. That day will forever be burned in my mind. After I release what happened I made mistake #2 I pulled the tail shaft of the arrow out of my hand causing more damage.
Thank goodness that my wife was home and was able to...