What rifle are you shooting? In my Lyman...my deer load is 80grs. of 2f Swiss with the 325gr. REAL bullet. Whitetails are all I've shot with it, but there's no muledeer that's gonna stand up to it either.
A good load for my rifle might be a horrible load for your rifle. Not just because they may have different barrel lengths and rates of twist, but also because each muzzleloader seems to be an individual, shooting differently than other muzzleloaders, even from the same manufacturer. Much more so than for modern cartridge guns.
What kind of gun do you have? What is its barrel length and rate of twist? That will influence whether you want to use a round ball, short conical, long conical, or even sabot (though sabots are illegal during muzzleloader season in some states). Once you have an idea of what kind of projectile you should be looking at, start experimenting until you come up with a load that's not too heavy, and shoots well and consistently.
Others have offered up a sighting of roughly 2 inches high at 100 yards as a good sighting scheme. In my own experience I have come to favor a sighting of 3.5 inches high at 100 yards. This allows for the individual to hold dead-on (directly in the middle of the top and bottom) the animal out to roughly 350 yards.
Magnum calibers such as the 7mm Remington and 300 Winchester will extend this slightly. At 400 yards I hold directly on the backbone of the animal. The drop at this range allows the...