I have spoken with 2 gentlement about 45 LC loads this month and they use the 45 Long Colt for deer in a hand gun. One of them is a Sierra Bulletsmith.
One thing for sure them heavier Rugers can shoot a much tougher load, I did see single action Ruger in 45LC with a 14" barrel, at a gun show, it made me want one.
Out here where I hunt a close shot is 300 yards, or it's running like hell,,,
Before I bought this Rossi in 45 LC all the web site said it shoot nice group at 100 yards,,,,,,,and shoot a dear at 150???????,, I still ain't got mine to do that good. But I is working on it.